The Human Genetic Hearing Loss Program of the University of Michigan, led by Dr. Margaret Lomax, Senior Research Scientist in the Department of Otolaryngology-Kresge Hearing Research Institute and Dr. Marci Lesperance, M.D., Assistant Professor of Otolaryngology-Head and Neck Surgery, is seeking volunteers for a study to identify genes that are responsible for otosclerosis.
Through the assistance of clinicians, researchers, and patients themselves we aim to:
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Identify and enroll families with otosclerosis |
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Map and clone genes responsible for hearing loss by using genetic linkage analysis and association studies |
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Gain understanding of ear development and function to provide a stronger foundation for effective treatment |
There is strong evidence that genes play a role in causing otosclerosis, and the participation of families is vital to identify these genes. Finding these genes will help explain how otosclerosis develops and may lead to new methods of diagnosis and treatment for future generations.
Individuals with otosclerosis, especially those with one or more relatives with otosclerosis (sisters, brothers, parents, children, cousins, aunts, uncles, grandparents, other)
Participation will involve completing a brief adult questionnaire or child questionnaire, signing a consent form, having a hearing test (or sending us a copy of a recent test), and donating a blood sample (for children, a cheek cell sample may be adequate). You will not be charged to participate, and any evaluation which is done for research purposes alone will be done at no cost to you or your insurance company. You will be contacted by a member of our team for additional information on your family. All information will be kept strictly confidential. Your participation in this study is completely voluntary. You can refuse to participate or withdraw from the study at any time.
Updated February, 2002.